Plasmin-mediated degradation of laminin γ-1 is critical for ethanol-induced neurodegeneration
AE Skrzypiec, R Maiya, Z Chen, R Pawlak… - Biological …, 2009 - Elsevier
BACKGROUND: Alcoholism may result in severe neurological deficits and cognitive
impairments. Many of the central effects of ethanol (EtOH) can be explained by upregulation
of N-methyl-D-aspartate (NMDA) and downregulation of gamma-aminobutyric acid (GABA)
A receptors (GABAA) in response to long-term EtOH consumption. Abrupt ethanol
withdrawal (EW) may result in neuronal hyperexcitability leading to hallucinations, seizures,
neurodegeneration, and sometimes death. METHODS: Using a multidisciplinary approach …
impairments. Many of the central effects of ethanol (EtOH) can be explained by upregulation
of N-methyl-D-aspartate (NMDA) and downregulation of gamma-aminobutyric acid (GABA)
A receptors (GABAA) in response to long-term EtOH consumption. Abrupt ethanol
withdrawal (EW) may result in neuronal hyperexcitability leading to hallucinations, seizures,
neurodegeneration, and sometimes death. METHODS: Using a multidisciplinary approach …
