[PDF][PDF] How to be naive
JV Stein - Immunity, 2009 - cell.com
Immunity, 2009•cell.com
How to be Naive Page 1 response. Several RGD motif-interacting integrins (v1, 31, v3, v5, v6,
51, M2, and L2) have previously been shown to serve as secondary receptors promoting Ad
internalization into different cell types in vitro. This study highlights the role of b3 integrins not
only for viral entry but also for IL-1a-driven inflammation. Like IL-1b, IL-1a is synthesized as a
preprotein, pre-IL-1a (Dinarello, 1996); however, unlike IL-1b, IL-1a is not processed by
caspase-1-containing inflammasomes. Rather, pre-IL1a is processed in the cytoplasm by …
51, M2, and L2) have previously been shown to serve as secondary receptors promoting Ad
internalization into different cell types in vitro. This study highlights the role of b3 integrins not
only for viral entry but also for IL-1a-driven inflammation. Like IL-1b, IL-1a is synthesized as a
preprotein, pre-IL-1a (Dinarello, 1996); however, unlike IL-1b, IL-1a is not processed by
caspase-1-containing inflammasomes. Rather, pre-IL1a is processed in the cytoplasm by …
The transcription factor KLF2 directs expression of receptors involved in trafficking of naive T cells. In this issue of Immunity, Weinreich et al. (2009) demonstrate that KLF2 additionally represses IL-4 production, which otherwise induces CXCR3 expression.
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