The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+ CD25+ T cells
K Mausner-Fainberg, G Luboshits, A Mor… - Atherosclerosis, 2008 - Elsevier
Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are in
widespread use due to their LDL reducing properties and concomitant improvement of
clinical outcome in patients with and without preexisting atherosclerosis. Considerable
evidence suggests that immune mediated mechanisms play a dominant role in the
beneficial effects of statins. Naturally occurring CD4+ CD25+ regulatory T cells (Tregs) have
a key role in the prevention of various inflammatory and autoimmune disorders by …
widespread use due to their LDL reducing properties and concomitant improvement of
clinical outcome in patients with and without preexisting atherosclerosis. Considerable
evidence suggests that immune mediated mechanisms play a dominant role in the
beneficial effects of statins. Naturally occurring CD4+ CD25+ regulatory T cells (Tregs) have
a key role in the prevention of various inflammatory and autoimmune disorders by …