NKG2D in NK and T cell-mediated immunity
K Ogasawara, LL Lanier - Journal of clinical immunology, 2005 - Springer
K Ogasawara, LL Lanier
Journal of clinical immunology, 2005•SpringerOne of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-
like membrane glycoprotein expressed on essentially all NK cells, as well as on γδ-TcR+ T
cells and αβ-TcR+ CD8+ T cells, in humans and mice. Here we review recent studies
implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its
potential role in autoimmune diseases and allogeneic bone marrow transplantation.
like membrane glycoprotein expressed on essentially all NK cells, as well as on γδ-TcR+ T
cells and αβ-TcR+ CD8+ T cells, in humans and mice. Here we review recent studies
implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its
potential role in autoimmune diseases and allogeneic bone marrow transplantation.
Abstract
One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on γδ-TcR+ T cells and αβ-TcR+ CD8+ T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.
Springer
