Aneuploidy often results from chromosome misalignment at metaphases. Oocytes from
senescence-accelerated mice (SAM) exhibit increased chromosome misalignment with age,
which originates from nuclear factors. This work sought to further characterize the underlying
defects of chromosome misalignments. Using immunofluorescence microscopy with specific
antibodies, several specific components associated with spindles or chromosomes,
including centrosomes, centromeres and cohesin complex were examined. No obvious …