[HTML][HTML] A transforming growth factor-β control element required for SM α-actin expression in vivo also partially mediates GKLF-dependent transcriptional repression
Y Liu, S Sinha, G Owens - Journal of Biological Chemistry, 2003 - ASBMB
We previously demonstrated that a conserved transforming growth factor-β control element
(TCE) within the 5′-region of the smooth muscle cell (SMC) differentiation marker gene SM
α-actin could mediate both transcriptional activation and repression in cultured SMCs
through interaction with members of the zinc finger Kruppel-like transcription factor (KLF)
family. The aims of the present studies were to: 1) determine the role of the SM α-actin TCE
in vivo through mutagenesis studies in transgenic mice and 2) further characterize the …
(TCE) within the 5′-region of the smooth muscle cell (SMC) differentiation marker gene SM
α-actin could mediate both transcriptional activation and repression in cultured SMCs
through interaction with members of the zinc finger Kruppel-like transcription factor (KLF)
family. The aims of the present studies were to: 1) determine the role of the SM α-actin TCE
in vivo through mutagenesis studies in transgenic mice and 2) further characterize the …
