Loss of tubular bone morphogenetic protein—7 in diabetic nephropathy
SN Wang, J Lapage, R Hirschberg - Journal of the American …, 2001 - journals.lww.com
Bone morphogenetic protein—7 (BMP7), a member of the transforming growth factor—β
(TGF—β) superfamily of cytokines, is highly expressed in renal tubules and generally
promotes maintenance of epithelial phenotype. It was examined whether, during the
evolution of experimental diabetic nephropathy, the renal expression of BMP7 and BMP7
receptors declines, and the hypothesis that loss of BMP7 activity is profibrogenic in proximal
tubular cells was tested. Moreover, in vitro studies in cultured proximal tubular cells were …
(TGF—β) superfamily of cytokines, is highly expressed in renal tubules and generally
promotes maintenance of epithelial phenotype. It was examined whether, during the
evolution of experimental diabetic nephropathy, the renal expression of BMP7 and BMP7
receptors declines, and the hypothesis that loss of BMP7 activity is profibrogenic in proximal
tubular cells was tested. Moreover, in vitro studies in cultured proximal tubular cells were …