The cell surface of Candida albicans is the immediate point of contact with the host. The
outer layer of the cell wall is enriched in highly glycosylated mannoproteins that are
implicated in many aspects of the host-fungus interaction. Glycosylation of cell wall proteins
is initiated in the endoplasmic reticulum and then elaborated in the Golgi as the protein
passes through the secretory pathway. Golgi-bound mannosyltransferases require Mn 2+ as
an essential cofactor. In Saccharomyces cerevisiae, the P-type ATPase Pmr1p transports Ca …