[PDF][PDF] Effect of short-term exercise on the content of gluconeogenic metabolites in rat liver and kidney
R Munoz-Clares, JP Garcia-Ruiz, A Vargas… - FEBS Lett, 1979 - core.ac.uk
R Munoz-Clares, JP Garcia-Ruiz, A Vargas, F Sanchez-Medina
FEBS Lett, 1979•core.ac.ukWe have reported that muscular exercise (swimming in water at 22'C for 2 h) enhances the
activity of phosphoenolpyruvate carboxykinase and the gluconeogenic capacity of rat kidney
cortex [I, 2]. These effects are probably mediated by the metabolic acidosis which takes
place during exercise as result of muscular overproduction of lactate [3]. The increase of
renal gluconeogenesis in experimental metabolic acidosis seems to be related to the
enhancement of the reaction catalyzed by phosphoenolpyruvate carboxykinase, as …
activity of phosphoenolpyruvate carboxykinase and the gluconeogenic capacity of rat kidney
cortex [I, 2]. These effects are probably mediated by the metabolic acidosis which takes
place during exercise as result of muscular overproduction of lactate [3]. The increase of
renal gluconeogenesis in experimental metabolic acidosis seems to be related to the
enhancement of the reaction catalyzed by phosphoenolpyruvate carboxykinase, as …
We have reported that muscular exercise (swimming in water at 22’C for 2 h) enhances the activity of phosphoenolpyruvate carboxykinase and the gluconeogenic capacity of rat kidney cortex [I, 2]. These effects are probably mediated by the metabolic acidosis which takes place during exercise as result of muscular overproduction of lactate [3].
The increase of renal gluconeogenesis in experimental metabolic acidosis seems to be related to the enhancement of the reaction catalyzed by phosphoenolpyruvate carboxykinase, as indicated by the concentrations of intermediate metabolites of this process [4, 5]. Consequently, we have measured the content of gluconeogenic intermediates in kidney after 2 h of swimming in order to obtain further evidence on the relation between the effect of exercise on gluconeogenesis and metabolic acidosis.
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