[HTML][HTML] The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity: macrophage expression of aP2 impacts …
L Makowski, KC Brittingham, JM Reynolds… - Journal of Biological …, 2005 - ASBMB
Fatty acid-binding proteins are cytosolic fatty acid chaperones, and the adipocyte isoform,
aP2, plays an important role in obesity and glucose metabolism. Recently, this protein has
been detected in macrophages where it strongly contributes to the development of
atherosclerosis. Here, we investigated the role of aP2 in macrophage biology and the
molecular mechanisms underlying its actions. We demonstrate that aP2-deficient
macrophages display defects in cholesterol accumulation and alterations in pro …
aP2, plays an important role in obesity and glucose metabolism. Recently, this protein has
been detected in macrophages where it strongly contributes to the development of
atherosclerosis. Here, we investigated the role of aP2 in macrophage biology and the
molecular mechanisms underlying its actions. We demonstrate that aP2-deficient
macrophages display defects in cholesterol accumulation and alterations in pro …
