Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells
L Li, S Cousart, J Hu, CE McCall - Journal of Biological Chemistry, 2000 - ASBMB
Interleukin-1 receptor-associated kinase (IRAK), a signal transducer for interleukin-1, has
also been suggested to participate in the Toll-like receptor-mediated innate immune
response to bacterial endotoxin lipopolysaccharide (LPS). Using the human promonocytic
THP-1 cell line, we demonstrated that the endogenous IRAK is quickly activated in response
to bacterial LPS stimulation, as measured by its in vitro kinase activity toward myelin basic
protein. LPS also triggers the association of IRAK with MyD88, the adaptor protein linking …
also been suggested to participate in the Toll-like receptor-mediated innate immune
response to bacterial endotoxin lipopolysaccharide (LPS). Using the human promonocytic
THP-1 cell line, we demonstrated that the endogenous IRAK is quickly activated in response
to bacterial LPS stimulation, as measured by its in vitro kinase activity toward myelin basic
protein. LPS also triggers the association of IRAK with MyD88, the adaptor protein linking …
