Differential effects of chronic ethanol administration on GABAA receptor α1 and α6 subunit mRNA levels in rat cerebellum
AL Morrow, JS Herbert, P Montpied - Molecular and Cellular Neuroscience, 1992 - Elsevier
Chronic ethanol exposure alters muscimol, pentobarbital, and benzodiazepine agonist and
inverse agonist effects on the function of GABA A receptor-gated Cl− channels in the central
nervous system (CNS). We have recently shown that prolonged ethanol inhalation reduces
the expression of GABA A receptor α1 and α2 subunit mRNAs in the rat cerebral cortex, with
no effect on the level of α3 subunit transcripts, glutamic acid decarboxylase mRNA levels, or
poly (A)+ RNA levels. In the present study, rats were administered alcohol by liquid diet for 2 …
inverse agonist effects on the function of GABA A receptor-gated Cl− channels in the central
nervous system (CNS). We have recently shown that prolonged ethanol inhalation reduces
the expression of GABA A receptor α1 and α2 subunit mRNAs in the rat cerebral cortex, with
no effect on the level of α3 subunit transcripts, glutamic acid decarboxylase mRNA levels, or
poly (A)+ RNA levels. In the present study, rats were administered alcohol by liquid diet for 2 …
