A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children
PE Graves, M Kabesch, M Halonen, CJ Holberg… - Journal of Allergy and …, 2000 - Elsevier
Background: Increased levels of total serum IgE are a strong risk factor for the development
of asthma. IgE is also involved in host defenses against parasites and fungi. Linkage of total
serum IgE with markers located close to the 3 Mb cluster of cytokine genes in chromosome
5q31 has been reported. IL-4 or IL-13 are regarded as essential for IgE synthesis. Objective:
We tested whether polymorphisms in the IL-13 gene might explain the linkage between
chromosome 5q31 and total serum IgE levels. Methods: We used denaturing HPLC to detect …
of asthma. IgE is also involved in host defenses against parasites and fungi. Linkage of total
serum IgE with markers located close to the 3 Mb cluster of cytokine genes in chromosome
5q31 has been reported. IL-4 or IL-13 are regarded as essential for IgE synthesis. Objective:
We tested whether polymorphisms in the IL-13 gene might explain the linkage between
chromosome 5q31 and total serum IgE levels. Methods: We used denaturing HPLC to detect …