[HTML][HTML] Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165
G Hashimoto, I Inoki, Y Fujii, T Aoki, E Ikeda… - Journal of Biological …, 2002 - ASBMB
Vascular endothelial growth factor (VEGF), a potent angiogenic mitogen, plays a crucial role
in angiogenesis under various pathophysiological conditions. We have recently
demonstrated that VEGF 165, one of the VEGF isoforms, binds connective tissue growth
factor (CTGF) and that its angiogenic activity is inhibited in the VEGF 165· CTGF complex
form (Inoki, I., Shiomi, T., Hashimoto, G., Enomoto, H., Nakamura, H., Makino, K., Ikeda, E.,
Takata, S., Kobayashi, K. and Okada, Y.(2002) FASEB J. 16, 219–221). In the present study …
in angiogenesis under various pathophysiological conditions. We have recently
demonstrated that VEGF 165, one of the VEGF isoforms, binds connective tissue growth
factor (CTGF) and that its angiogenic activity is inhibited in the VEGF 165· CTGF complex
form (Inoki, I., Shiomi, T., Hashimoto, G., Enomoto, H., Nakamura, H., Makino, K., Ikeda, E.,
Takata, S., Kobayashi, K. and Okada, Y.(2002) FASEB J. 16, 219–221). In the present study …