[HTML][HTML] Modulation of the endothelial nitric-oxide synthase-caveolin interaction in cardiac myocytes: implications for the autonomic regulation of heart rate
The endothelial isoform of nitric oxide synthase (eNOS) is dually acylated and thereby
targeted to signal-transducing microdomains termed caveolae. In endothelial cells, eNOS
interacts with caveolin-1, which represses eNOS enzyme activity. In cardiac myocytes, eNOS
associates with the muscle-specific caveolin-3 isoform, but whether this interaction affects
NO production and regulates myocyte function is unknown. We isolated neonatal cardiac
myocytes from mutant mice with targeted disruption of the eNOS gene and transfected them …
targeted to signal-transducing microdomains termed caveolae. In endothelial cells, eNOS
interacts with caveolin-1, which represses eNOS enzyme activity. In cardiac myocytes, eNOS
associates with the muscle-specific caveolin-3 isoform, but whether this interaction affects
NO production and regulates myocyte function is unknown. We isolated neonatal cardiac
myocytes from mutant mice with targeted disruption of the eNOS gene and transfected them …