[HTML][HTML] Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90
W Xu, E Mimnaugh, MFN Rosser, C Nicchitta… - Journal of biological …, 2001 - ASBMB
ErbB receptors are a family of ligand-activated tyrosine kinases that play a central role in
proliferation, differentiation, and oncogenesis. ErbB2 is overexpressed in> 25% of breast
and ovarian cancers and is correlated with poor prognosis. Although ErbB2 and ErbB1 are
highly homologous, they respond quite differently to geldanamycin (GA), an antibiotic that is
a specific inhibitor of the chaperone protein Hsp90. Thus, although both mature and nascent
ErbB2 proteins are down-regulated by GA, only nascent ErbB1 is sensitive to the drug. To …
proliferation, differentiation, and oncogenesis. ErbB2 is overexpressed in> 25% of breast
and ovarian cancers and is correlated with poor prognosis. Although ErbB2 and ErbB1 are
highly homologous, they respond quite differently to geldanamycin (GA), an antibiotic that is
a specific inhibitor of the chaperone protein Hsp90. Thus, although both mature and nascent
ErbB2 proteins are down-regulated by GA, only nascent ErbB1 is sensitive to the drug. To …
