Immunoglobulin heavy chain toxicity in plasma cells is neutralized by fusion to pre-B cells.
IG Haas, MR Wabl - … of the National Academy of Sciences, 1984 - National Acad Sciences
IG Haas, MR Wabl
Proceedings of the National Academy of Sciences, 1984•National Acad SciencesA plasma cell hybridoma frequently loses its immunoglobulin heavy (H) chain
spontaneously but rarely is production of its light (L) chain lost. Upon fusion to a pre-B-cell
hybridoma that produces no Ig chain, the L chain is frequently lost. In cells without the L
chain the H chain, which is derived from the plasma cell, is not chemically modified. Our
results indicate that, in pre-B cells, but not in plasma cells, there must be a mechanism that
neutralizes the toxic effect of free H chain.
spontaneously but rarely is production of its light (L) chain lost. Upon fusion to a pre-B-cell
hybridoma that produces no Ig chain, the L chain is frequently lost. In cells without the L
chain the H chain, which is derived from the plasma cell, is not chemically modified. Our
results indicate that, in pre-B cells, but not in plasma cells, there must be a mechanism that
neutralizes the toxic effect of free H chain.
A plasma cell hybridoma frequently loses its immunoglobulin heavy (H) chain spontaneously but rarely is production of its light (L) chain lost. Upon fusion to a pre-B-cell hybridoma that produces no Ig chain, the L chain is frequently lost. In cells without the L chain the H chain, which is derived from the plasma cell, is not chemically modified. Our results indicate that, in pre-B cells, but not in plasma cells, there must be a mechanism that neutralizes the toxic effect of free H chain.
National Acad Sciences