Differences in angiogenic potential of classically vs alternatively activated macrophages
V Kodelja, C Müller, S Tenorio, C Schebesch… - Immunobiology, 1997 - Elsevier
Macrophages (MΦ) are important for angiogenesis during inflammation, wound repair, and
tumor growth. However, well-characterized MΦ subsets such as IFN-γ-induced, classically
activated (ca) MΦ or IL-4/glucocorticoid-induced, alternatively activated (aa) MΦ have not
been thoroughly examined for a positive or negative association with angiogenesis. While
caMΦ populate early inflammatory reactions and high-turnover granulomas, aaMΦ occur in
healing wounds and chronic inflammation. In contrast to caMΦ-dominated lesions, aaMΦ …
tumor growth. However, well-characterized MΦ subsets such as IFN-γ-induced, classically
activated (ca) MΦ or IL-4/glucocorticoid-induced, alternatively activated (aa) MΦ have not
been thoroughly examined for a positive or negative association with angiogenesis. While
caMΦ populate early inflammatory reactions and high-turnover granulomas, aaMΦ occur in
healing wounds and chronic inflammation. In contrast to caMΦ-dominated lesions, aaMΦ …
