[HTML][HTML] Leukotriene B4 stimulates Rac-ERK cascade to generate reactive oxygen species that mediates chemotaxis
CH Woo, HJ You, SH Cho, YW Eom, JS Chun… - Journal of Biological …, 2002 - ASBMB
Leukotriene B 4 is a potent chemoattractant known to be involved mainly in inflammation,
immune responses, and host defense against infection, although the exact signaling
mechanisms by which it exerts its effects are not well understood. Here we show that
exogenous leukotriene B 4 induces reactive oxygen species (ROS) generation via a Rac-
dependent pathway, and that stable expression of Rac N17, a dominant negative Rac1
mutant, completely blocks leukotriene B 4-induced ROS generation. In addition, leukotriene …
immune responses, and host defense against infection, although the exact signaling
mechanisms by which it exerts its effects are not well understood. Here we show that
exogenous leukotriene B 4 induces reactive oxygen species (ROS) generation via a Rac-
dependent pathway, and that stable expression of Rac N17, a dominant negative Rac1
mutant, completely blocks leukotriene B 4-induced ROS generation. In addition, leukotriene …