Endothelin-1 induces cyclooxygenase-2 expression via nuclear factor of activated T-cell transcription factor in glomerular mesangial cells
T Sugimoto, M Haneda, H Sawano… - Journal of the …, 2001 - journals.lww.com
Nuclear factor of activated T cells (NFAT) originally was identified as a T-cell—specific
transcription factor whose activity is regulated by calcineurin, one of the serine-threonine
phosphatases. Recent studies have shown that NFAT also is expressed in nonlymphoid
cells and plays an important role in various cell functions. It is widely known that treatment
with cyclosporin A (CsA), which can inhibit calcineurin/NFAT signaling, results in glomerular
dysfunction characterized by a decrease of GFR or glomerulosclerosis, suggesting that …
transcription factor whose activity is regulated by calcineurin, one of the serine-threonine
phosphatases. Recent studies have shown that NFAT also is expressed in nonlymphoid
cells and plays an important role in various cell functions. It is widely known that treatment
with cyclosporin A (CsA), which can inhibit calcineurin/NFAT signaling, results in glomerular
dysfunction characterized by a decrease of GFR or glomerulosclerosis, suggesting that …
