[HTML][HTML] Identification of an endothelial cell-specific regulatory region in the murine endothelin-1 gene
X Bu, T Quertermous - Journal of Biological Chemistry, 1997 - ASBMB
Endothelin-1 is a 21-amino acid peptide first characterized as a potent vasoactive
compound synthesized by endothelial cells. Because of its high level cell-restricted pattern
of expression, we have employed this gene as a model for investigating the DNA and
protein elements that mediate endothelial cell-specific gene expression. In this study we
have identified a complex positive regulatory region located at base pairs− 364 to− 320 in
the murine endothelin-1 gene. This region consists of three functionally dependent …
compound synthesized by endothelial cells. Because of its high level cell-restricted pattern
of expression, we have employed this gene as a model for investigating the DNA and
protein elements that mediate endothelial cell-specific gene expression. In this study we
have identified a complex positive regulatory region located at base pairs− 364 to− 320 in
the murine endothelin-1 gene. This region consists of three functionally dependent …
