An array of sunshine in multiple sclerosis

DA Dyment, GC Ebers - New England Journal of Medicine, 2002 - Mass Medical Soc
New England Journal of Medicine, 2002Mass Medical Soc
Multiple sclerosis is the most common nontraumatic disorder of the central nervous system
in young adults. Twenty years after the onset of disease, 90 percent of cases will have
entered a progressive phase. Strong circumstantial evidence implicates an autoimmune
mechanism in multiple sclerosis. The results of family studies illustrate the importance of
genes in the familial aggregation of the disease. However, most monozygotic twins are
discordant for the disease, and the markedly reduced risk of susceptible populations in …
Multiple sclerosis is the most common nontraumatic disorder of the central nervous system in young adults. Twenty years after the onset of disease, 90 percent of cases will have entered a progressive phase.
Strong circumstantial evidence implicates an autoimmune mechanism in multiple sclerosis. The results of family studies illustrate the importance of genes in the familial aggregation of the disease. However, most monozygotic twins are discordant for the disease, and the markedly reduced risk of susceptible populations in subtropical regions demonstrates the substantial role of environmental effects.
As in many putatively autoimmune diseases, susceptibility to multiple sclerosis is governed in . . .
The New England Journal Of Medicine