Effects of adrenergic agonists and adenosine on cholinergic neurotransmission in human tracheal smooth muscle
TR Bai, R Lam, FYF Prasad - Pulmonary pharmacology, 1989 - Elsevier
There is only limited information available on the prejunctional regulation of acetylcholine
(ACh) release from cholinergic nerves in human airway smooth muscle. Stimulation of
cholinergic nerves in fresh postmortem tracheal muscle strips with electrical field stimulation
(EFS) causes reproducible contractions. We have studied the effect on contractile responses
of: 1) The α 2-adrenoceptor agonist effect of noradrenaline (NA, 0.1–30 μM) and clonidine
(10 nM–30 μM), in the presence of 1 μM propranolol and prazosin±idazoxan (0.1 μM); 2) …
(ACh) release from cholinergic nerves in human airway smooth muscle. Stimulation of
cholinergic nerves in fresh postmortem tracheal muscle strips with electrical field stimulation
(EFS) causes reproducible contractions. We have studied the effect on contractile responses
of: 1) The α 2-adrenoceptor agonist effect of noradrenaline (NA, 0.1–30 μM) and clonidine
(10 nM–30 μM), in the presence of 1 μM propranolol and prazosin±idazoxan (0.1 μM); 2) …
