[HTML][HTML] Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region
Y Xu, Q Yu - Journal of Biological Chemistry, 2001 - ASBMB
Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) affect angiogenesis differently during
embryogenesis and tumorigenesis. In an attempt to understand the molecular basis
underlying the distinct roles of those two homologous molecules, we investigated the
association of Ang-1 and Ang-2 with the extracellular matrix (ECM). TA3 murine mammary
carcinoma (TA3) and Lewis lung carcinoma cells expressing v5 epitope-tagged Ang-1 and
Ang-2 were used in our studies. The results indicated that Ang-1 is secreted and …
embryogenesis and tumorigenesis. In an attempt to understand the molecular basis
underlying the distinct roles of those two homologous molecules, we investigated the
association of Ang-1 and Ang-2 with the extracellular matrix (ECM). TA3 murine mammary
carcinoma (TA3) and Lewis lung carcinoma cells expressing v5 epitope-tagged Ang-1 and
Ang-2 were used in our studies. The results indicated that Ang-1 is secreted and …