Chloride channels are involved in a multitude of physiologic processes ranging from basal
cellular functions such as cell volume regulation and acidification of intracellular vesicles to
more specialized mechanisms such as vectorial transepithelial transport and regulation of
cellular excitability. This plethora of functions is accomplished by numerous functionally
highly diverse chloride channels that are only partially identified at the molecular level. The
CLC family of chloride channels comprises at present nine members in mammals that differ …