[HTML][HTML] Tissue source dictates lineage outcome of human fetal CD34+ CD38− cells
MC Poznansky, IT Olszak, RB Foxall, A Piascik… - Experimental …, 2001 - Elsevier
OBJECTIVE: The translocation from fetal liver hematopoiesis to secondary organs occurs
during the second trimester of human gestation. It has been hypothesized that stem cells
migrate and acquire lineage potential based on cues specific to the adopted
microenvironment. We evaluated primitive hematopoietic cell populations in the fetal human
to determine if lineage restriction precedes or follows translocation to sites of hematopoietic
activity including thymus, spleen, bone marrow, and liver. METHODS: Sets of hematopoietic …
during the second trimester of human gestation. It has been hypothesized that stem cells
migrate and acquire lineage potential based on cues specific to the adopted
microenvironment. We evaluated primitive hematopoietic cell populations in the fetal human
to determine if lineage restriction precedes or follows translocation to sites of hematopoietic
activity including thymus, spleen, bone marrow, and liver. METHODS: Sets of hematopoietic …