[HTML][HTML] Internalization and sequestration of the human prostacyclin receptor
EM Smyth, SC Austin, MP Reilly… - Journal of Biological …, 2000 - ASBMB
Prostacyclin (PGI 2), the major product of cyclooxygenase in macrovascular endothelium,
mediates its biological effects through its cell surface G protein-coupled receptor, the IP.
PKC-mediated phosphorylation of human (h) IP is a critical determinant of agonist-induced
desensitization (Smyth, EM, Hong Li, W., and FitzGerald, GA (1998) J. Biol. Chem. 273,
23258–23266). The regulatory events that follow desensitization are unclear. We have
examined agonist-induced sequestration of hIP. Human IP, tagged at the N terminus with …
mediates its biological effects through its cell surface G protein-coupled receptor, the IP.
PKC-mediated phosphorylation of human (h) IP is a critical determinant of agonist-induced
desensitization (Smyth, EM, Hong Li, W., and FitzGerald, GA (1998) J. Biol. Chem. 273,
23258–23266). The regulatory events that follow desensitization are unclear. We have
examined agonist-induced sequestration of hIP. Human IP, tagged at the N terminus with …
