[HTML][HTML] Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2
Z Yang, DK Strickland, P Bornstein - Journal of Biological Chemistry, 2001 - ASBMB
We have recently shown that the adhesive defect observed in dermal fibroblasts derived
from thrombospondin 2 (TSP2)-null mice results from an increase in matrix
metalloproteinase 2 (MMP2) levels (Yang, Z., Kyriakides, TR, and Bornstein, P.(2000) Mol.
Biol. Cell 11, 3353–3364). Adhesion was restored by replacement of TSP2 and by inhibitors
of MMP2 activity. In pursuing the observation that TSP2 and MMP2 interact, we now
demonstrate that this interaction is required for optimal clearance of extracellular MMP2 by …
from thrombospondin 2 (TSP2)-null mice results from an increase in matrix
metalloproteinase 2 (MMP2) levels (Yang, Z., Kyriakides, TR, and Bornstein, P.(2000) Mol.
Biol. Cell 11, 3353–3364). Adhesion was restored by replacement of TSP2 and by inhibitors
of MMP2 activity. In pursuing the observation that TSP2 and MMP2 interact, we now
demonstrate that this interaction is required for optimal clearance of extracellular MMP2 by …
