Vaccination with streptococcal extracellular cysteine protease (interleukin-1β convertase) protects mice against challenge with heterologous group A streptococci
V Kapur, JT Maffei, RS Greer, LL Li, GJ Adams… - Microbial …, 1994 - Elsevier
Virtually all clinical isolates of group A streptococci secrete a highly conserved extracellular
cysteine protease that cleaves human fibronectin and vitronectin, and converts IL-1β
precursor to biologically active IL-1β. Based on the high degree of gene conservation within
the species and its role in host pathogenicity, it was postulated that antibodies to the
cysteine protease would confer protective immunity against S. pyogenes infection. To test
this hypothesis, Swiss CD1 mice were intraperitoneally administered either saline, rabbit …
cysteine protease that cleaves human fibronectin and vitronectin, and converts IL-1β
precursor to biologically active IL-1β. Based on the high degree of gene conservation within
the species and its role in host pathogenicity, it was postulated that antibodies to the
cysteine protease would confer protective immunity against S. pyogenes infection. To test
this hypothesis, Swiss CD1 mice were intraperitoneally administered either saline, rabbit …
